1. **Regardless of either quantity or potency, cannabis cannot cause lethal overdose in humans**:
– Calabria, B., Degenhardt, L., Hall, W., & Lynskey, M. (2010). Does cannabis use increase the risk of death? Systematic review of epidemiological evidence on adverse effects of cannabis use. *Drug and Alcohol Review*, 29(3), 318-330.
– Volkow, N. D., Baler, R. D., Compton, W. M., & Weiss, S. R. (2014). Adverse health effects of marijuana use. *New England Journal of Medicine*, 370(23), 2219-2227.
2. **State-based cannabis legalization has lowered crime rates**:
– Morris, R. G., TenEyck, M., Barnes, J. C., & Kovandzic, T. V. (2014). The effect of medical marijuana laws on crime: evidence from state panel data, 1990-2006. *PloS One*, 9(3), e92816.
3. **In states where medical cannabis is legal, opioid-related mortality has fallen significantly**:
– Bachhuber, M. A., Saloner, B., Cunningham, C. O., & Barry, C. L. (2014). Medical cannabis laws and opioid analgesic overdose mortality in the United States, 1999-2010. *JAMA Internal Medicine*, 174(10), 1668-1673.
4. **Cannabis is more likely to be used as an “exit” from dangerous drugs than to act as a “gateway” drug**:
– Lucas, P., Reiman, A., Earleywine, M., McGowan, S. K., Oleson, M., Coward, M. P., & Thomas, B. (2016). Cannabis as a substitute for alcohol and other drugs: A dispensary-based survey of substitution effect in Canadian medical cannabis patients. *Addictive Behaviors*, 64, 27-34.
– Lucas, P., & Walsh, Z. (2017). Medical cannabis access, use, and substitution for prescription opioids and other substances: A survey of authorized medical cannabis patients. *International Journal of Drug Policy*, 42, 30-35.